Evolution of the relaxin-like peptide family

Table 2 GenBank accession numbers for relaxin-like sequences. Accession numbers for all sequences included in the phylogeny are listed. New sequences identified in this study are highlighted in bold and accession numbers shown in brackets underneath. Phylogenetic analyses showed TrRLX3f, DrRLX3c, XtRLX3a and XlRLX3 sequences (shown in italics) to be relaxin rather than relaxin-3 homologs and are therefore listed in the relaxin (RLX2) column.

Species	RLX1	RLX2	RLX3	INSL3	INSL4	INSL5	INSL6
Human	P04808	P04090	Q8WXF3	P51460	Q14641	Q9Y5Q6	Q9Y581
Chimpanzee	S42783	P51455	BK005156 ^b	BK005155 ^b	BK005152 ^b	BK005153 ^b	BK005154 ^b
Mouse	-	CAA81611	Q8CHK2	O09107	-	Q9WUG6	Q9QY05
Rat	-	J00780	Q8BFS3	AAD33663	-	-	Q9WV41
Dog	-	Q9TRM8	AAEX01023146	AAEX01022997			AAEX01053723
Wallaby		AAM22209
R. esculenta		CAC16108
Fugufish		*RLX3f* BK005388 ^b	RLX3a-c			RLX3d,e
Zebrafish		*RLX3c* BK005255 ^b	RLX3a BK005228			RLX3b BK005252^a,b RLX3d (^b,c)
Chicken			RLX3a BK005146^a			RLX3b BK005533^b
Pig		P01348	Q8HY17	P51461
X. tropicalis		*RLX3a* BK005229 ^a	RLX3b(^b,d) RLX3c(^b,d)
X. laevis		*RLX3* BK005230 ^a
O. mykiss						RLX3 BK005147^a
M. mulatta					INSL4 BK005251^a

^aSequences determined from multiple overlapping ESTs.
^bSequences determined from genomic data.
^cSequence from the Ensembl zebrafish genome assembly [68](GENSCAN00000013529 on supercontig NA8544).
^dSequence from the Xenopus genome v2.0 [58].

ISSN: 2730-7182